解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::Direct brain injections of the N-methyl-D-aspartate receptor agonist quinolinic acid (QA) trigger an excitotoxic cascade characterized by rapid neuronal death and glial/immune cell activation. The present study compared the timing of immediate early gene (IEG; c-fos, c-jun, jun-B, and zif/268) induction with the respo...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.490360511
更新日期:1993-12-01 00:00:00
abstract::Plexiform layer synaptic and photoreceptor cell components were investigated in retinas of Royal College of Surgeons (RCS) dystrophic rats transplanted with normal retinal pigment epithelial (RPE) cells by immunocytochemistry using previously characterized monoclonal antibodies. In retinas of normal adult rats and RPE...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.490360408
更新日期:1993-11-01 00:00:00
abstract::F5 was identified originally as an interleukin-2-regulated gene in L2 cells, a murine helper T-lymphocyte clone. In adult mouse, F5 mRNA was expressed at a modest level in lymphoid tissues, at a high level in mature neurons in the nervous system, but not in other tissues. Although the F5 sequence is highly conserved o...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.490360308
更新日期:1993-10-15 00:00:00
abstract::The immunohistochemical distribution of microtubule-associated protein 2 (MAP2), being normally restricted to nerve cell bodies and dendrites, became altered in rat dorsal root ganglia and spinal cord neurons in cultures infected with rhesus rotavirus. MAP2 appeared in axons of both sources of neurons as displayed wit...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.490360207
更新日期:1993-10-01 00:00:00
abstract::Nascent neural crest cells derived from explanted E12 embryonic rat caudal neural tubes were used as an assay system to investigate the effects of fibroblast growth factors on neural crest cell (NCC) survival, proliferation, migration, and differentiation. In vitro and in vivo all NCC express low affinity nerve growth...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.490360106
更新日期:1993-09-01 00:00:00
abstract::Electrical activity shapes development of the nervous system, presumably in part by regulating gene expression. A set of regulatory genes, immediate early genes (IEGs), which are responsive to a number of extrinsic cellular stimuli have been proposed to play a role in coupling such activity to gene expression. Using a...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.490350502
更新日期:1993-08-01 00:00:00
abstract::Neurotrophins may have a neuroprotective role and are probably involved in the control of axonal sprouting and synaptic plasticity. An antibody raised against a pro-sequence of nerve growth factor (NGF) was tested. In control undisturbed rats, a strong immunoreactivity was detected in scattered cells in and around the...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.490350409
更新日期:1993-07-01 00:00:00
abstract::The production of collagen-degrading proteases by cultured neonatal rat microglia was examined using an immobilized fibronectin-gelatin matrix coupled to a fluorescent marker and by substrate gel analysis. When microglia were plated onto the surface of the matrix and incubated under resting (nonstimulated) conditions,...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.490350309
更新日期:1993-06-15 00:00:00
abstract::The cholinergic system takes part in the immune-neuroendocrine integration. Lymphocytes have been found to express muscarinic and nicotinic cholinergic receptors, as well as acetylcholine-esterase on their surface, and cholinergic agents modulate immune functions in vitro and in vivo. In the present study we provide e...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.490350209
更新日期:1993-06-01 00:00:00
abstract::To investigate the function of the dipeptide carnosine in the olfactory system, alterations of carnosine in the primary olfactory nerve after unilateral naris closure or olfactory bulb semilesion were studied by means of immunocytochemistry. After unilateral naris closure, carnosine staining showed no alteration, but ...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.490340608
更新日期:1993-04-15 00:00:00
abstract::Neurotrophic factors regulate the developmental survival and differentiation of specific neuronal populations. Brain-derived neurotrophic factor (BDNF) and neurotrophin-3 (NT-3) are members of the nerve growth factor (NGF) protein family, also known as the neurotrophins. Insights into the different roles of neurotroph...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.490340602
更新日期:1993-04-15 00:00:00
abstract::Protein kinase C (PKC) and its potential role in myelin gene expression were investigated in primary cultured rat oligodendrocytes. The major myelin genes were expressed in a developmentally coordinated manner in cultured oligodendrocytes. PKC activity in these cells was similarly regulated with differential expressio...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.490340509
更新日期:1993-04-01 00:00:00
abstract::The development of cells of the oligodendroglial lineage, from immature progenitor to myelinating cells, occurs largely in a neuronal environment, yet little is known about specific interactions between these 2 cell types. We have tested the effects of medium conditioned by cultures of rat cerebral cortical neurons (C...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.490340510
更新日期:1993-04-01 00:00:00
abstract::An elevated expression of c-fos nuclear protooncogene (immediate early gene) has been shown repeatedly to correlate with long-term neuronal responses. This paper reviews recent data suggesting that neuronal plasticity, including learning and memory formation, may involve c-fos expression as well. On the basis of biolo...
journal_title:Journal of neuroscience research
pub_type: 杂志文章,评审
doi:10.1002/jnr.490340402
更新日期:1993-03-01 00:00:00
abstract::The occurrence of type-1 plasminogen activator inhibitor (PAI-1) in human cerebrospinal fluid (CSF) has not previously been reported. As a member of the serpin superfamily of serine protease inhibitors and an acute phase response component, PAI-1 has powerful potential roles in nervous system homeostasis. We have dete...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.490340311
更新日期:1993-02-15 00:00:00
abstract::Our aim has been to investigate the ability of the rat brain to retain its level of neurotransmitter release over life. We have investigated the neurotransmitter release from the rat brain synaptosomes prelabeled with 3H-DA, 3H-NA, or 3H-5HT, and perfused with Krebs-Ringer medium alone (basal release) or containing a ...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.490340314
更新日期:1993-02-15 00:00:00
abstract::Fractionation of muscle microsomes rich in sarcoplasmic reticulum (SR) by isopicnic centrifugation yielded three types of membranes. Heavy (HM), intermediate (IM), and light membranes (LM), with isopicnic points of 38, 33, and 25% w/w sucrose, were rich in terminal cisternae/triads, longitudinal SR, and T-tubules, res...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.490330409
更新日期:1992-12-01 00:00:00
abstract::Pharmacological characterization of the action of the novel non-N-methyl-D-aspartate (non-NMDA) antagonist AMOA (2-amino-3-[3-(carboxymethoxy)-5-methylisoxazol-4-yl]propionate) on glutamate receptors was investigated in Xenopus oocytes injected with mouse brain mRNA. AMOA (150 microM) produced a nearly parallel shift ...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.490330305
更新日期:1992-11-01 00:00:00
abstract::We studied the postischemic alterations of second messenger and receptor systems focusing on the strionigral pathway in order to clarify the mechanism of the delayed neuronal changes in remote areas of the rat brain after transient focal ischemia. Chronological changes of [3H]forskolin and [3H]SCH 23390 binding sites ...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.490330315
更新日期:1992-11-01 00:00:00
abstract::Cultures of dissociated hypothalamic cells taken from rat fetuses of 19 days of gestation were studied using time-lapse recording and sequential microphotography from 1 to 5 days in vitro (DIV) and at 7 and 21 DIV. Cultures were seeded with cells taken from fetuses grouped by sex or sexually mixed; experimental cultur...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.490330210
更新日期:1992-10-01 00:00:00
abstract::Previous studies have demonstrated variability in the phenotype of rat C6 glioma cells. In the present study, we compared morphology, growth rate, and beta-adrenergic regulation of gene expression in early (P39-47) and late (P55-90) passage C6 cells. Morphological changes were observed in five independently derived, l...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.490330213
更新日期:1992-10-01 00:00:00
abstract::Understanding the pathway for amyloid percursor protein (APP) catabolism has become an important line of investigation. APP is a ubiquitous membrane bound protein that is rapidly cleaved at the membrane, yielding a secreted protein identical to protease nexin II and an internalized 11.5 kDa 100 residue C terminal deri...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.490330121
更新日期:1992-09-01 00:00:00
abstract::Fibroblast growth factors (FGFs) are known to act on glial cells in vitro. At the present time, their involvement in the remyelinating process of the adult central nervous system (CNS) is still unknown. In the present study, using immunohistochemistry (IHC), we investigated the evolution in time and space of acidic FG...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.490330107
更新日期:1992-09-01 00:00:00
abstract::We describe an experimental model to produce closed traumatic injuries to the spinal cord of adult rats. This model uses an inflatable balloon that is introduced in the dorsal subdural space and moved to a location rostral to the laminectomy site. The spinal cord trauma can be graded by varying either the duration of ...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.490320409
更新日期:1992-08-01 00:00:00
abstract::Nerve growth factor (NGF) has a modulating effect on immune function, which may occur as a consequence of binding to the NGF receptor (NGF-R). To determine if mRNA for the gene coding for p75NGFR (low affinity NGF-R) is present in lymphocytes, Northern blot analysis of mRNA from human peripheral blood lymphocytes (PBL...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.490320316
更新日期:1992-07-01 00:00:00
abstract::A frontal pole cDNA library from monkey (Macaca mulatta) brain was screened to identify mRNAs that are expressed more in frontal pole as compared to primary visual cortex. Three cDNA clones, whose greater expression was confirmed by Northern blot analysis, were identified as cytochrome oxidase (COX) subunits I, II, an...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.490320313
更新日期:1992-07-01 00:00:00
abstract::We have previously shown that the phorbol ester, TPA, which activates protein kinase C, causes, in PC12 cells, a transcriptional activation of tyrosine hydroxylase (TH), the key enzyme in catecholamine synthesis. The study has now been extended to examine the processes that underlie this transcriptional stimulation an...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.490320219
更新日期:1992-06-01 00:00:00
abstract::Four brain-specific, DNase I hypersensitive sites (HSS) have been mapped to the 5' flanking region of the mouse 68-kDa neurofilament gene. These sites are contained within a 1.7-kb sequence that confers neuronal specificity of expression of this gene in transgenic mice. To identify DNA sequences that might be involved...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.490320204
更新日期:1992-06-01 00:00:00
abstract::A Schwann cell line (MSC 80) was established from purified mouse Schwann cell cultures using large doses of serum. MSC 80 cell line is an aneuploid cell line which has a doubling time of 17 hr and has been maintained through more than 110 passages. Most of MSC 80 cells are of bipolar or stellate (3-5 processes) shape....
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.490320103
更新日期:1992-05-01 00:00:00
abstract::The transport kinetics of the excitatory sulphur-containing amino acid (SAA) transmitter candidates, L-cysteine sulphinate (L-CSA), L-cysteate (L-CA), L-homocysteine sulphinate (L-HCSA), and L-homocysteate (L-HCA), together with their plasma membrane carrier specificity, was studied in cerebrocortical synaptosome frac...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.490320108
更新日期:1992-05-01 00:00:00
abstract::Previous studies have identified a group of cells in the dorsolateral hypothalamus that project to many different areas in the CNS, such as thalamus, diagonal band of Broca, basal ganglia, cerebral cortex, hippocampus, and olfactory bulb. Their role is presently unknown, but the cells have been reported to stain for a...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.490310415
更新日期:1992-04-01 00:00:00
abstract::Miniature endplate potentials (MEPPs) with slow rising phase can be attributed either to burst of transmitter releases or to distortion of conduction from remote releasing sites. The spontaneous activity of neuromuscular junctions recorded extracellularly at mouse diaphragms using sharp electrodes was analyzed to test...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.490310313
更新日期:1992-03-01 00:00:00
abstract::To examine the role of platelet-derived growth factor (PDGF) in the in vivo regulation of Schwann cell proliferation, steady-state levels of mRNAs encoding PDGF A and B chains, and PDGF alpha and beta receptors were measured in immature and adult rat sciatic nerves and in cultured rat Schwann cells. PDGF B chain and P...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.490310206
更新日期:1992-02-01 00:00:00
abstract::The types of cells contacted by growth cones were examined in chick-quail and vice versa chimeras. Simultaneously, the presence of nonspecific cholinesterase (nChE) was monitored in developing peripheral nerves of these embryos. In all the chimeras studied, the growth cones were in contact with both Schwann cell proge...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.490310211
更新日期:1992-02-01 00:00:00
abstract::The neuron-glia cell adhesion molecule (Ng-CAM) mediates neuron-neuron adhesion by a homophilic mechanism and neuron-astrocyte adhesion by a heterophilic mechanism. The protein is expressed on neurons and Schwann cells but not on astrocytes. It is most prevalent during development on cell bodies of migrating neurons a...
journal_title:Journal of neuroscience research
pub_type: 杂志文章,评审
doi:10.1002/jnr.490310102
更新日期:1992-01-01 00:00:00
abstract::The mutant hypogonadal (hpg) mouse lacks a functioning gene for the neurohormone gonadotropin releasing hormone (GnRH). Previous studies from our laboratory had indicated that the initiation and maintenance of reproductive function in these mice could be brought about by the implantation of normal fetal grafts into ad...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.490310121
更新日期:1992-01-01 00:00:00
abstract::The effects of hyposmotic conditions on taurine uptake and release were studied in mice cultured cerebellar granule cells. The effect of DIDS (4,4'-diisothiocyanatostilbene-2,2'-disulfonate) and of the divalent cations Mg++ and Mn++ on the hyposmolarity-induced changes in these parameters was investigated. Mg++ (20 mM...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.490300409
更新日期:1991-12-01 00:00:00
abstract::Our previous work indicated that in E14 embryonic rat spinal cord cultures ciliary neuronotrophic factor (CNTF) exerted (1) a survival-promoting effect on motor neurons and on a large population of unidentified neurons, and (2) a regulatory role on the expression of ChAT and low affinity NGF receptor (LNGFR) in a popu...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.490300314
更新日期:1991-11-01 00:00:00
abstract::We have shown that ethanol exposure during embryogenesis affects a variety of parameters of neuronal growth. In this study we examined the direct effects of ethanol exposure on developing neuroblasts in culture. Neuroblast-enriched cultures derived from 3-day-old whole chick embryos were grown in the presence of ethan...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.490300305
更新日期:1991-11-01 00:00:00
abstract::We have recently reported a potent mitogenic stimulation of oligodendroglial (OL) progenitors by the protein kinase C (PKC) activating phorbol ester, i.e., phorbol 12-myristate 13-acetate (PMA) (Bhat NR, J Neurosci Res 22:20-27, 1989). The present study deals with PMA-induced protein phosphorylation reactions in cultu...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.490300222
更新日期:1991-10-01 00:00:00